Opportunity Information: Apply for PAR 22 097
The National Institutes of Health (NIH) is offering the grant opportunity "Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional)" under Funding Opportunity Number PAR-22-097. This announcement is a reissue intended to correct earlier errors and omissions, and it supports R01 research projects that address brain and other nervous system function and disorders across the entire lifespan, with a clear focus on issues that are relevant in low- and middle-income countries (LMICs). The scope is intentionally broad, covering neurological, mental, behavioral, alcohol, and substance use disorders, and it welcomes projects ranging from basic and translational science through clinical, public health, and implementation research. Clinical trials may be included, but they are optional rather than required.
A central goal of the FOA is to stimulate innovative and genuinely collaborative research partnerships between U.S. scientists and scientists based in LMIC institutions. The emphasis is on work that is meaningful for LMIC settings, which often implies attention to local disease burden, context-specific risk and protective factors, feasibility and scalability of interventions, health system constraints, and equity in research design and benefits. In addition to U.S.-LMIC collaborations, the FOA specifically allows scientists in upper middle-income LMICs (UMICs) to partner directly with researchers at other LMIC institutions, with or without a U.S. partner. Eligibility of countries is tied to World Bank income classifications, referenced in the FOA via the World Bank country and lending group categories.
The opportunity uses the NIH grant mechanism and is categorized as a discretionary grant. It sits within the broad activity areas of environment, health, income security, and social services, reflecting the wide-ranging determinants and consequences of nervous system and mental health conditions. Multiple CFDA numbers are associated with this FOA (93.113, 93.173, 93.242, 93.853, 93.865, 93.866, 93.867, 93.989), which signals participation across different NIH institutes and centers and, by extension, a wide scientific remit. While the listing does not specify an award ceiling or the expected number of awards, it is structured as a standard NIH R01, which typically supports substantial, multi-year research programs commensurate with the proposed aims and justified budget.
Eligible applicants are expansive and include many types of U.S. and non-U.S. organizations. On the U.S. side, eligibility includes state, county, city/township, special district governments, independent school districts, and public housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; and a variety of nonprofit and for-profit entities (including small businesses and other for-profit organizations that are not small businesses). Tribal eligibility includes federally recognized Native American tribal governments and other tribal organizations, as well as Indian/Native American tribal governments that are not federally recognized in the "Other Eligible Applicants" section. The FOA also highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-U.S.) entities/foreign organizations, and U.S. territories or possessions. This broad eligibility is consistent with the FOA's intent to encourage cross-sector and cross-region collaboration and to ensure that research teams can be built around the expertise and infrastructure needed for LMIC-relevant neuroscience and mental health research.
Key administrative details from the source listing include an original closing date of 2024-12-09 and a creation date of 2022-02-08. Overall, this FOA is designed to fund strong, collaborative R01 projects that advance understanding, prevention, diagnosis, treatment, and/or implementation of solutions for brain and nervous system disorders in LMIC contexts, while encouraging equitable international partnerships and allowing flexibility in study type, including but not limited to clinical trials.Apply for PAR 22 097
- The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.242, 93.853, 93.865, 93.866, 93.867, 93.989.
- This funding opportunity was created on 2022-02-08.
- Applicants must submit their applications by 2024-12-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
1) What is the name of this NIH funding opportunity?
The opportunity is titled "Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional)".
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-22-097.
3) What type of award mechanism does this opportunity use?
This announcement supports projects under the NIH R01 research project grant mechanism.
4) Are clinical trials required?
No. Clinical trials are optional under this FOA. Projects may include clinical trials, but they are not required.
5) What is the overall focus of the FOA?
The FOA funds research addressing brain and other nervous system function and disorders across the entire lifespan, with a clear focus on issues that are relevant in low- and middle-income countries (LMICs).
6) Which scientific areas and disorders are within scope?
The scope is intentionally broad and includes work related to neurological, mental, behavioral, alcohol, and substance use disorders.
7) What stages of research are supported?
The FOA welcomes a wide range of approaches, including basic science, translational science, clinical research, public health research, and implementation research.
8) What does "across the lifespan" mean in this context?
It means projects can address nervous system and brain-related function or disorders at any life stage, from early life through older adulthood, as long as the proposed work is relevant to LMIC settings.
9) What is a central goal of this FOA besides funding research projects?
A central goal is to stimulate innovative and genuinely collaborative research partnerships, particularly between U.S. scientists and scientists based in LMIC institutions.
10) Does the FOA require that the research be meaningful for LMIC settings?
Yes. The emphasis is on research that is meaningful for LMIC settings, often implying attention to local disease burden, context-specific risk and protective factors, feasibility and scalability, health system constraints, and equity in research design and benefits.
11) Are collaborations required to include a U.S. partner?
Not always. The FOA specifically allows scientists in upper middle-income LMICs (UMICs) to partner directly with researchers at other LMIC institutions, with or without a U.S. partner.
12) How is LMIC (and UMIC) eligibility determined?
Eligibility of countries is tied to World Bank income classifications, referenced via the World Bank country and lending group categories.
13) What kinds of applicant organizations are eligible in the United States?
Eligibility includes a wide range of U.S. entities such as:
- State, county, city/township, and special district governments
- Independent school districts
- Public housing authorities
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations
- For-profit organizations, including small businesses and other for-profit entities that are not small businesses
14) Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments and other tribal organizations, and it also includes Indian/Native American tribal governments that are not federally recognized (as listed under "Other Eligible Applicants").
15) Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA includes non-domestic (non-U.S.) entities/foreign organizations among eligible applicants.
16) Are U.S. territories and possessions eligible?
Yes. U.S. territories or possessions are included in the eligible applicant categories.
17) Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly highlights faith-based or community-based organizations as eligible applicants.
18) Are minority-serving institutions (MSIs) specifically highlighted as eligible?
Yes. The FOA highlights eligibility for multiple MSI categories, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISISs)
19) Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies among applicant types.
20) Does the listing provide an award ceiling or expected number of awards?
No. The listing does not specify an award ceiling or the expected number of awards.
21) If the listing does not provide a maximum award amount, what does it imply about the scale of projects?
It is structured as a standard NIH R01, which typically supports substantial, multi-year research programs commensurate with the proposed aims and a justified budget.
22) What does it mean that this is a "reissue" announcement?
The announcement is a reissue intended to correct earlier errors and omissions in a prior version of the opportunity.
23) What type of grant is this categorized as in the source listing?
It is categorized as a discretionary grant using the NIH grant mechanism.
24) What broad activity areas does this FOA fall under?
The opportunity is described as sitting within broad activity areas including environment, health, income security, and social services, reflecting wide determinants and consequences of nervous system and mental health conditions.
25) Which CFDA numbers are associated with this FOA?
The listing associates multiple CFDA numbers with this FOA: 93.113, 93.173, 93.242, 93.853, 93.865, 93.866, 93.867, 93.989.
26) What does the presence of multiple CFDA numbers suggest?
It signals participation across different NIH institutes and centers, and by extension a wide scientific remit for the research supported.
27) What is the original closing date provided in the source listing?
The original closing date listed is 2024-12-09.
28) What is the creation date provided in the source listing?
The creation date listed is 2022-02-08.
29) What kinds of real-world LMIC considerations does the FOA encourage applicants to address?
Based on the description, the FOA encourages attention to considerations such as local disease burden, context-specific risk and protective factors, feasibility and scalability of interventions, health system constraints, and equity in research design and benefits.
30) What outcomes or impacts is this FOA aiming to support?
The FOA is designed to fund collaborative R01 projects that advance understanding, prevention, diagnosis, treatment, and/or implementation of solutions for brain and nervous system disorders in LMIC contexts.
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