Opportunity Information: Apply for RFA AG 22 004

The NIA Research and Entrepreneurial Development Immersion (REDI) Mentored Entrepreneurial Career Development Award is a National Institutes of Health (NIH) funding opportunity from the National Institute on Aging (NIA) designed to help early-career investigators build toward research independence through a structured, mentored career development experience. It is a K01 award mechanism, and it specifically does not allow clinical trials. The core aim is to provide substantial protected time and support over a multi-year period so that a promising researcher can deepen their expertise, expand their research skills, and develop a clear trajectory to becoming an independent investigator in biomedical, behavioral, or clinical science areas relevant to aging.

This opportunity supports an intensive, supervised career development plan lasting three to five years. In practical terms, the award is meant to buy time: time to train, to publish, to build an intellectual and technical niche, and to assemble the preliminary data and professional track record typically needed to compete for independent research awards later on. While the title highlights "Research and Entrepreneurial Development Immersion (REDI)," the framing indicates an emphasis on developing research independence with an added orientation toward entrepreneurial or translational thinking, meaning the program is likely intended to help researchers better understand how to move ideas, tools, interventions, or discoveries toward real-world use, without the award itself being a vehicle for running a clinical trial.

The funding opportunity is listed as discretionary and uses the grant funding instrument. The activity category is health, and the CFDA number provided is 93.866. The opportunity number is RFA-AG-22-004, with a creation date of June 10, 2021, and an original closing date of September 29, 2021. The excerpted source data does not provide an award ceiling or the expected number of awards, so those specifics are not available from the text provided.

A wide range of applicant organizations are eligible. Eligible applicants include multiple levels of government (state, county, city or township, and special district governments), independent school districts, and federally recognized Native American tribal governments. Higher education institutions are eligible across categories, including public and state-controlled institutions of higher education as well as private institutions of higher education. Housing authorities (public housing authorities/Indian housing authorities) are included, along with Native American tribal organizations that are not federally recognized tribal governments. The eligibility list also spans nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in those nonprofit categories), for-profit organizations other than small businesses, and small businesses. The opportunity also explicitly calls out additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), eligible federal government agencies, faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American Tribal Governments other than federally recognized entities, regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions.

At the same time, there are clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities, described as foreign organizations or foreign institutions, are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible. The notice further states that foreign components, as defined in the NIH Grants Policy Statement, are not allowed. In other words, the project and its components need to be fully domestic under NIH policy, and applicants should plan the work accordingly.

Overall, this REDI K01 opportunity is best understood as a mentored career development award from NIA that funds several years of protected time and structured mentorship to help a researcher mature into an independent investigator, with the explicit condition that the proposed work cannot include a clinical trial and with strict limits against foreign entities or foreign components.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIA Research and Entrepreneurial Development Immersion (REDI): Mentored Entrepreneurial Career Development Award (K01 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
  • This funding opportunity was created on 2021-06-10.
  • Applicants must submit their applications by 2021-09-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA AG 22 004

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Frequently Asked Questions (FAQs)

What is the NIA Research and Entrepreneurial Development Immersion (REDI) Mentored Entrepreneurial Career Development Award?

It is a National Institutes of Health (NIH) funding opportunity from the National Institute on Aging (NIA) that supports early-career investigators through a structured, mentored career development experience designed to build toward research independence. The award uses the K01 career development mechanism and focuses on helping investigators deepen expertise, expand research skills, and establish a clear trajectory to become independent investigators in aging-relevant research areas.

What is the main purpose of this award?

The core purpose is to provide substantial protected time and support over multiple years so a promising researcher can develop professionally and scientifically toward independence. In practical terms, the award is meant to "buy time" for training, publishing, building a focused research niche, and generating preliminary data and a track record that can support future independent research funding.

What NIH activity mechanism does this opportunity use?

This opportunity uses the K01 award mechanism (a mentored career development award).

Are clinical trials allowed under this funding opportunity?

No. The opportunity explicitly does not allow clinical trials.

How long can the supported career development plan last?

The opportunity supports an intensive, supervised career development plan lasting three to five years.

What research areas does the opportunity support?

The award supports development toward independence in biomedical, behavioral, or clinical science areas relevant to aging.

What does "REDI" imply in this opportunity?

Based on the description provided, the "Research and Entrepreneurial Development Immersion (REDI)" framing indicates an emphasis on research independence with an added orientation toward entrepreneurial or translational thinking. This suggests the program is intended to help researchers better understand pathways for moving ideas, tools, interventions, or discoveries toward real-world use, while still operating within the stated restriction that the award itself cannot include a clinical trial.

What type of funding instrument is used?

The opportunity uses the grant funding instrument.

How is this opportunity categorized?

The activity category is health.

What is the CFDA number for this opportunity?

The CFDA number provided is 93.866.

What is the opportunity number?

The opportunity number is RFA-AG-22-004.

When was this opportunity created and when did it originally close?

The creation date is June 10, 2021. The original closing date is September 29, 2021.

Is there information on the award ceiling or the expected number of awards?

No. The source information provided does not include an award ceiling or an expected number of awards.

Who is eligible to apply?

The eligibility list provided is broad and includes multiple types of U.S.-based organizations, including:

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Federally recognized Native American tribal governments
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Housing authorities (public housing authorities/Indian housing authorities)
  • Native American tribal organizations (other than federally recognized tribal governments)
  • Nonprofits with 501(c)(3) status (other than institutions of higher education in that nonprofit category)
  • Nonprofits without 501(c)(3) status (other than institutions of higher education in that nonprofit category)
  • For-profit organizations other than small businesses
  • Small businesses
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
  • Eligible federal government agencies
  • Faith-based or community-based organizations
  • Hispanic-serving institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Indian/Native American tribal governments other than federally recognized entities
  • Regional organizations
  • Tribally Controlled Colleges and Universities (TCCUs)
  • U.S. territories or possessions

Are foreign (non-U.S.) organizations eligible to apply?

No. Foreign organizations or foreign institutions (non-domestic, non-U.S. entities) are not eligible to apply.

Can a U.S. organization include a non-U.S. (foreign) component in the project?

No. Non-domestic components of U.S. organizations are not eligible. The notice also states that foreign components (as defined in the NIH Grants Policy Statement) are not allowed, meaning the project and its components need to be fully domestic under NIH policy.

Does the opportunity indicate whether it is discretionary?

Yes. The opportunity is listed as discretionary.

What is the overall takeaway about what this award supports?

It is best understood as a mentored NIA K01 career development award providing several years of protected time and structured mentorship to help an early-career researcher mature into an independent investigator in aging-relevant science, with two clear constraints: the proposed work cannot include a clinical trial, and foreign entities or foreign components are not allowed.

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