Opportunity Information: Apply for RFA AA 24 008
The Comprehensive Alcohol Research Centers (P60 Clinical Trial Optional) funding opportunity (RFA-AA-24-008) is a National Institutes of Health (NIH) discretionary grant designed to build and sustain large, coordinated research centers focused on alcohol-related science. It uses the NIH Comprehensive Research Center (P60) mechanism, which is intended for long-term, multidisciplinary, and multi-investigator programs rather than single, standalone projects. The core idea is to support an integrated research enterprise organized around one clear, major research theme in alcohol research, along with the shared research support activities needed to keep that enterprise productive and cohesive over time. Because the notice is labeled "Clinical trial optional," applicants may propose clinical trials if they fit the center theme, but clinical trials are not required.
This opportunity sits within the health funding category and is associated with CFDA number 93.273. The program is administered by the National Institutes of Health, and the emphasis on a broad-based center structure signals that successful applications will typically show strong collaboration across disciplines, a clear plan for multiple investigators to work together under a unifying scientific vision, and well-defined shared resources or activities that enable the center to operate as more than the sum of its parts. In practical terms, the P60 model commonly supports several interrelated research projects plus center-wide infrastructure, such as administrative coordination and other shared support functions that strengthen productivity, data quality, and cross-project integration.
Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts. Higher education institutions are eligible, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal entities are also included, such as federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. The notice also allows applications from public housing authorities/Indian housing authorities. Nonprofit organizations may apply whether or not they hold 501(c)(3) status, as long as they are not institutions of higher education. For-profit organizations (other than small businesses) and small businesses are also listed as eligible, along with an "other" category that can capture additional qualifying entities.
The notice explicitly calls out additional eligible applicant categories that NIH encourages, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). It also includes faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and Indian/Native American Tribal Governments (other than federally recognized). These categories broaden the range of institutions that can lead a center and align with NIH interest in expanding participation and capacity across diverse communities and institution types.
At the same time, there are clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" as defined in the NIH Grants Policy Statement are allowed, meaning a U.S. applicant can include certain foreign elements in the research plan if they meet NIH policy requirements and are appropriately justified. This distinction matters: leadership and the applicant organization must be domestic, but specific foreign collaborations or performance sites may be permissible as foreign components under NIH rules.
Key administrative details provided in the source data include the original closing date of November 15, 2024, and an award ceiling of $1,250,000. The funding opportunity was created on May 7, 2024. The expected number of awards is not specified in the provided excerpt, so applicants would typically look to the full NOFO for any additional guidance on anticipated funding levels, budget structure, project period expectations, review criteria, and required center components.
Overall, this NOFO is aimed at establishing or advancing comprehensive alcohol research centers that can tackle complex alcohol-related scientific questions through coordinated, theme-driven collaboration. Competitive proposals generally need to convey a strong central theme, a well-integrated set of research and support activities, and the leadership and institutional environment necessary to manage a long-term, multi-investigator research program at the scale expected for a P60 center grant.Apply for RFA AA 24 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Comprehensive Alcohol Research Centers (P60 Clinical trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on 2024-05-07.
- Applicants must submit their applications by 2024-11-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs) - Comprehensive Alcohol Research Centers (P60 Clinical Trial Optional) (RFA-AA-24-008)
What is this funding opportunity?
This opportunity is the Comprehensive Alcohol Research Centers (P60 Clinical Trial Optional) funding opportunity, identified as RFA-AA-24-008. It is a National Institutes of Health (NIH) discretionary grant intended to build and sustain large, coordinated research centers focused on alcohol-related science.
What type of grant mechanism is used?
The program uses the NIH Comprehensive Research Center (P60) mechanism. This mechanism is designed for long-term, multidisciplinary, and multi-investigator research center programs rather than single, standalone research projects.
What is the main purpose of a P60 alcohol research center under this NOFO?
The main purpose is to support an integrated research enterprise organized around one clear, major research theme in alcohol research, along with shared research support activities needed to keep the center productive, cohesive, and coordinated over time.
Does the center have to focus on a single theme?
Yes. The core concept described emphasizes one clear, major research theme in alcohol research that unifies the center and helps integrate multiple investigators and activities into a cohesive program.
Is this opportunity focused on individual projects or an integrated center?
It is focused on an integrated center. The P60 model commonly supports several interrelated research projects plus center-wide infrastructure and shared support functions so the center operates as more than the sum of its parts.
Are clinical trials required?
No. The notice is labeled "Clinical trial optional," meaning clinical trials may be proposed if they fit the center theme, but they are not required.
Can an application include a clinical trial?
Yes. Because the NOFO is "Clinical trial optional," applicants may propose clinical trials as part of the center if they align with the proposed central theme and overall center design.
What funding category does this opportunity fall under?
It sits within the health funding category and is administered by the National Institutes of Health (NIH).
What is the CFDA number associated with this program?
The CFDA number associated with this opportunity is 93.273.
Who administers this grant?
The program is administered by the National Institutes of Health (NIH).
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and governments. Eligible applicants include various levels of government, eligible educational institutions, tribal entities, public housing authorities/Indian housing authorities, nonprofits, for-profits, and small businesses, along with an "other" category for additional qualifying entities.
Are state and local governments eligible?
Yes. Eligible government applicants include state governments, county governments, city or township governments, special district governments, and independent school districts.
Are institutions of higher education eligible?
Yes. Eligible higher education applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list includes federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. The notice also references Indian/Native American Tribal Governments (other than federally recognized) among additional eligible categories.
Are nonprofits eligible to apply?
Yes. Nonprofit organizations may apply whether or not they hold 501(c)(3) status, as long as they are not institutions of higher education.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among the additional eligible applicant categories mentioned in the notice.
Are federal agencies eligible to apply?
Yes. The notice includes eligible federal agencies among the additional eligible applicant categories.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included among the additional eligible applicant categories described in the opportunity information.
Does NIH encourage applications from certain institution types?
Yes. The notice explicitly calls out additional eligible applicant categories NIH encourages, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can a foreign (non-U.S.) organization apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
Are foreign collaborations allowed at all?
Yes, in a limited sense. While the applicant organization must be domestic, "foreign components" (as defined in the NIH Grants Policy Statement) are allowed. This means a U.S. applicant may include certain foreign elements in the research plan if they meet NIH policy requirements and are appropriately justified.
What is the difference between an ineligible foreign applicant and an allowed foreign component?
The leadership and applicant organization must be U.S.-based (domestic). However, certain foreign collaborations or performance sites may be included as "foreign components" under NIH policy if properly justified and compliant with NIH requirements.
What is the application deadline provided in the opportunity details?
The source information lists an original closing date of November 15, 2024.
When was this funding opportunity created?
The funding opportunity was created on May 7, 2024.
What is the maximum award amount (award ceiling)?
The award ceiling listed in the provided information is $1,250,000.
How many awards will NIH make?
The expected number of awards is not specified in the provided excerpt. Applicants would typically refer to the full NOFO for any guidance on anticipated award counts.
What kinds of activities are commonly supported in a P60 center structure?
The P60 model commonly supports several interrelated research projects plus center-wide infrastructure. Examples mentioned include administrative coordination and other shared support functions that strengthen productivity, data quality, and cross-project integration.
What does NIH likely expect in a competitive center application based on the description provided?
Based on the description provided, competitive applications will typically show strong collaboration across disciplines, a clear plan for multiple investigators to work together under a unifying scientific vision, and well-defined shared resources or activities that support integration and cohesive center operations over time.
Is this grant intended for short-term research?
No. The P60 mechanism is intended for long-term, coordinated center programs rather than short-term or single-project efforts.
Where should applicants look for details not included in the excerpt (for example, review criteria or required components)?
The excerpt notes that applicants would typically look to the full NOFO for additional guidance on items such as anticipated funding levels, budget structure, project period expectations, review criteria, and required center components.
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